PHACTR4 antibody

Catalog No. ABIN7117389

This anti-PHACTR4 antibody is a Rabbit Polyclonal antibody detecting PHACTR4 in WB, ELISA and IF. Suitable for Human, Mouse and Rat.

Quick Overview for PHACTR4 antibody (ABIN7117389)

Target: PHACTR4 (Phosphatase and Actin Regulator 4 (PHACTR4))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PHACTR4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Product Details anti-PHACTR4 Antibody

Purpose: PHACTR4 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: phosphatase and actin regulator 4

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IF: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for PHACTR4

Target: PHACTR4 (Phosphatase and Actin Regulator 4 (PHACTR4))

Alternative Name: PHACTR4

Background:

Synonyms: Phosphatase and actin regulator 4|PHACTR4

Background: Regulator of protein phosphatase 1(PP1) required for neural tube and optic fissure closure, and enteric neural crest cell(ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells(ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin(COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway(By similarity).

Molecular Weight: 71-85 kDa

Gene ID: 65979

UniProt: Q8IZ21

Pathways: Tube Formation